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Classification and structure The superfamily of the glutathione transferases are divided into at least four major families of proteins, namely cytosolic or soluble GSTs, mitochondrial GSTs, microsomal GSTs and bacterial fosfomycin-resistance proteins [39], [6], [69]

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39 The outcome of these studies reinforces the notion that the intestinal epithelium is essential for separating luminal antigens from mucosal immune components, and that its disruption by altered proliferation/apoptosis ratio can result in immune activation and inflammation (Figure 1)

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